I'm a huge Guru-fan, and still think it's one of the easiest ways to explore rythm production intuitively. So imagine my horror to find that after installing High Sierra it didn't work!
The stand-alone version exhibits the following symptoms
User interface = OK
Meters showing activity = OK
Preferences shows up all interfaces = OK
No sound! = Broken
The plugin used to work OK with 32 lives, but LPX now refuses to load it, removing it from the list of plugins.